Make your covalent hits matter.

Identify druggable regulatory sites by overlaying your chemoproteomic maps with novel regulatory hotspots.

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Your problems

Chemoproteomic maps produce many unexplained hotspots.
Hard-to-drug proteins lack clear allosteric handles.
Fragment hits often have no mechanistic rationale.
Choosing the wrong target wastes years.

Our solution

We surface high-confidence regulatory cysteine sites that make your maps interpretable and actionable.

What You Get

Integration is effortless, fitting directly into your existing chemoproteomics workflows.

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CSV Export

Predicted regulatory cysteine sites (UniProt + residue + confidence + evidence stack)

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Annotated Models

PDB/AlphaFold models with highlighted hotspots

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Mechanistic Dossiers

Structured dossiers per site with domain context and evidence

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Interactive Viewer

Optional web viewer for exploring evidence

How It Works

1
Predict

Physiological regulatory cysteine sites using structural, evolutionary, pathway, and redox context.

2
Annotate

Each site with domain context, ligandability, PTM competition, and disease-variant proximity.

3
Deliver

Decision-ready reports aligned to existing chemoproteomic frameworks.

Who This Is For

If you use covalent maps, this makes them more valuable.

Chemoproteomics Teams
Covalent Platform Scientists
Structural Biology / Biophysics Groups
Mechanism-of-Action Teams
Target Discovery Leaders
Computational Chemistry / ML Teams

Ready to Get Started?

Request free access to browse modification sites of 1000 compounds.

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